Paul J Brindley Selected Research

Schistosomiasis haematobia (Schistosomiasis haematobium)

1/2020	IPSE, an abundant egg-secreted protein of the carcinogenic helminth Schistosoma haematobium, promotes proliferation of bladder cancer cells and angiogenesis.
1/2020	Estrogen receptors in urogenital schistosomiasis and bladder cancer: Estrogen receptor alpha-mediated cell proliferation.
1/2019	Infection with carcinogenic helminth parasites and its production of metabolites induces the formation of DNA-adducts.
1/2018	The small RNA complement of adult Schistosoma haematobium.
3/2017	The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer.
6/2015	The role of estrogens and estrogen receptor signaling pathways in cancer and infertility: the case of schistosomes.
4/2015	Estrogen-like metabolites and DNA-adducts in urogenital schistosomiasis-associated bladder cancer.
1/2014	Schistosome and liver fluke derived catechol-estrogens and helminth associated cancers.
1/2014	Urinary estrogen metabolites and self-reported infertility in women infected with Schistosoma haematobium.
1/2013	Tumour-like phenotypes in urothelial cells after exposure to antigens from eggs of Schistosoma haematobium: an oestrogen-DNA adducts mediated pathway?

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Paul J Brindley Research Topics

Disease

54	Infections 01/2022 - 07/2002
34	Neoplasms (Cancer) 09/2023 - 06/2007
32	Opisthorchiasis 10/2022 - 11/2008
18	Cholangiocarcinoma 01/2024 - 01/2009
18	Schistosomiasis (Bilharziasis) 01/2022 - 02/2006
13	Fibrosis (Cirrhosis) 05/2021 - 10/2009
12	Carcinogenesis 01/2021 - 06/2007
11	Inflammation (Inflammations) 05/2023 - 08/2008
11	Schistosomiasis haematobia (Schistosomiasis haematobium) 01/2020 - 03/2008
7	Urinary Bladder Neoplasms (Bladder Cancer) 01/2020 - 07/2011
7	Vesicular Stomatitis 10/2016 - 04/2006
5	Wounds and Injuries (Trauma) 10/2018 - 10/2015
4	Neglected Diseases 01/2022 - 01/2012
4	Reinfection 01/2021 - 08/2008
3	Persistent Infection 01/2022 - 10/2012
3	Bile Duct Neoplasms (Bile Duct Cancer) 01/2021 - 01/2012
3	Communicable Diseases (Infectious Diseases) 01/2019 - 06/2005
3	Leukemia 12/2010 - 04/2006
3	Microsporidiosis 06/2006 - 05/2005
2	Clonorchiasis 08/2021 - 11/2019
2	Helminthiasis (Helminthiases) 01/2021 - 01/2019
2	Granuloma 01/2021 - 01/2019
2	Insulin Resistance 11/2019 - 08/2017
2	Coinfection 01/2018 - 01/2015
2	Infertility (Sterility) 06/2015 - 01/2014
2	Nasopharyngeal Carcinoma 12/2014 - 01/2014
2	Fibrosarcoma 06/2012 - 06/2011
1	Liver Cirrhosis (Hepatic Cirrhosis) 03/2022
1	Strongyloidiasis 01/2021
1	Hyperplasia 01/2020
1	Parasitic Diseases (Parasitic Disease) 11/2019
1	Non-alcoholic Fatty Liver Disease 11/2019
1	Filarial Elephantiasis (Lymphatic Filariasis) 04/2019
1	Filariasis 04/2019

Drug/Important Bio-Agent (IBA)

15	CarcinogensIBA 03/2022 - 06/2007
14	Proteins (Proteins, Gene)FDA Link 01/2022 - 02/2006
14	VaccinesIBA 01/2021 - 02/2006
13	Biomarkers (Surrogate Marker)IBA 03/2022 - 01/2012
10	Praziquantel (Biltricide)FDA Link 05/2021 - 03/2013
9	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 03/2023 - 10/2009
8	CytokinesIBA 09/2023 - 07/2002
8	Glycoproteins (Glycoprotein)IBA 03/2023 - 04/2006
8	GranulinsIBA 01/2022 - 10/2015
8	EnzymesIBA 01/2019 - 03/2008
7	MicroRNAs (MicroRNA)IBA 05/2023 - 01/2014
7	TetraspaninsIBA 01/2022 - 01/2012
7	AntigensIBA 08/2021 - 02/2006
6	AnthelminticsIBA 01/2021 - 09/2011
6	DNA AdductsIBA 05/2020 - 01/2014
6	Estrogens (Estrogen)FDA Link 01/2019 - 01/2014
6	Peptide Hydrolases (Proteases)FDA Link 01/2018 - 07/2002
5	AntibodiesIBA 10/2022 - 11/2008
5	Immunoglobulin G (IgG)IBA 10/2022 - 03/2012
5	OxysterolsIBA 05/2020 - 12/2013
5	Interleukin-6 (Interleukin 6)IBA 06/2017 - 10/2009
3	Subunit VaccinesIBA 01/2022 - 04/2020
3	Small Interfering RNA (siRNA)IBA 01/2021 - 06/2011
3	Estrogen ReceptorsIBA 01/2020 - 06/2015
3	RNA (Ribonucleic Acid)IBA 01/2018 - 01/2014
3	Messenger RNA (mRNA)IBA 08/2017 - 06/2011
3	LuciferasesIBA 06/2012 - 04/2006
2	ProgranulinsIBA 03/2023 - 01/2020
2	NitrosaminesIBA 01/2022 - 05/2011
2	SterolsIBA 05/2020 - 01/2014
2	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 01/2014
2	Proliferating Cell Nuclear Antigen (PCNA)IBA 09/2018 - 01/2018
2	8-Hydroxy-2'-DeoxyguanosineIBA 01/2018 - 01/2015
2	IgYIBA 08/2017 - 12/2015
2	Cathepsin FIBA 08/2017 - 12/2015
2	Cysteine Proteases (Cysteine Protease)IBA 12/2015 - 03/2008
2	catechol (pyrocatechol)IBA 11/2015 - 04/2015
2	QuinonesIBA 04/2015 - 01/2014
2	Formaldehyde (Formol)FDA Link 12/2014 - 03/2012
2	Catechol EstrogensIBA 01/2014 - 01/2014
2	Reactive Oxygen Species (Oxygen Radicals)IBA 03/2012 - 08/2008
2	AnnexinsIBA 10/2011 - 03/2010
2	fumagillinIBA 06/2006 - 05/2005
2	Albendazole (Albenza)FDA Link 06/2005 - 05/2005
1	Monoclonal AntibodiesIBA 07/2021
1	Lamivudine (Epivir)FDA Link 01/2021
1	Hormones (Hormone)IBA 01/2021
1	Retroelements (Retrotransposon)IBA 01/2021
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2021
1	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 01/2021
1	SteroidsIBA 01/2021
1	matrigelIBA 11/2020
1	Phosphotransferases (Kinase)IBA 11/2020
1	Leucyl Aminopeptidase (Peptidase S)IBA 04/2020
1	Estrogen Receptor alphaIBA 01/2020
1	Phenobarbital (Luminal)FDA Link 01/2020
1	LipidsIBA 11/2019
1	FructoseIBA 11/2019
1	Cytochrome P-450 CYP1A1 (CYP1A1)IBA 01/2019
1	Membrane Proteins (Integral Membrane Proteins)IBA 01/2019
1	Protein Isoforms (Isoforms)IBA 01/2019

Therapy/Procedure

7	Therapeutics 01/2024 - 06/2005
4	Drug Therapy (Chemotherapy) 01/2021 - 03/2008
3	Mass Drug Administration 01/2017 - 08/2008
1	Immunotherapy 01/2021
1	Lab-On-A-Chip Devices 04/2019